This Byzantine Cathedral is the oldest church in Vrontados, the inscription on its entrance informs the visitors for its historicity. It was renovated in 1746, burned in 1821 and reconstructed radically in 1893 after several repairs. Several sacred heirlooms and remains are kept in this church: a piece of the Holy Cross, some of the remains of Agios Georgios Tropeoforos, stones from the Holy Sepulcher and Golgotha (Calvary) amaze the visitors giving a deeper aspect to their pilgrimage. The Holy Kara (Head) of Stamatios Hartoularis, who died for his religion and his country (was slaughtered in 1822 while he was celebrating Mass), is also kept in the church of Agios Georgios.